NCRI promotes innovative brain research using the latest advancements in neuroimaging to inquire about mechanisms of the nature and extent of central nervous system involvement in neurological disorders. Here, we utilize eLORETA, sLORETA or swLORETA, all of which derive their information from a quantitative electroencephalography (qEEG) record. If you are mathematically inclined, the system used to derive the LORETA measures is called the inverse solution (read more at Grech et al, 2008). Using these latest electrical neuroimaging methods to examine information flow within networks, we can measure brain dysregulation (if it exists), linking this information to patient symptoms and complaints. These integrative methods characterize the dysregulation found within brain systems which cause the disease process. In this manner, our applied research methods provide assessment, treatment monitoring, diagnosis, and observing the course of illness, all with a 3-minute qEEG record, done in a quiet room. This equipment is a fraction of the cost of fMRI and other modalities, so we can conduct our research for a fraction of the cost of typical neuroimaging methods.
Here at NCRI, we focus on rare and poorly-understood neurological disorders as well as cognitive impairment resulting from illnesses, organ transplants, viral infections, critical illness, and other severe medical conditions. To develop better understandings and treatments for these disorders, we must look at diverse areas such as how movement is created, how the brain predicts the future, and why cognitive impairment does result from seemingly unrelated problems such as being in the ICU, having the flu or receiving a lung transplant. Neurological impairment can, and does, result from many types of insults. If there is a pathogen which travels to the brain, it does brain damage through the inflammation inherent in encephalitis.
We are also interested in how the brain compensates for neurological insults, including how the brain engages its compensatory mechanisms so as to continue working in the face of damage from disease or injury. Compensatory mechanisms attest to the brain’s incredible ability to re-work itself. Unfortunately, many patients who do have brain damage appear normal on neuropsychological tests, sometimes as a result of this compensation. Therefore, another research goal is to characterize brain damage separately from the brain’s normal compensatory abilities, allowing researchers to develop even more effective rehabilitation programs and helping those with brain damage.